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In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) () is an enzyme that catalyzes the chemical reaction :(R)-mevalonate + CoA + 2 NADP+ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme. == Nomenclature == The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include: * hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide * adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase * β-hydroxy-β-methylglutaryl coenzyme A reductase * hydroxymethylglutaryl CoA reductase (NADPH) * S-3-hydroxy-3-methylglutaryl-CoA reductase * NADPH-hydroxymethylglutaryl-CoA reductase * HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA) * 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) * hydroxymethylglutaryl-CoA reductase (NADPH2). 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Hydroxymethylglutaryl-CoA reductase (NADPH)」の詳細全文を読む スポンサード リンク
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