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・ Hydroxylammonium sulfate
・ Hydroxylapatite
・ Hydroxylated lecithin
・ Hydroxylation
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・ Hydroxymalonate dehydrogenase
・ Hydroxymandelonitrile glucosyltransferase
・ Hydroxymandelonitrile lyase
・ Hydroxymatairesinol
・ Hydroxymethyl
・ Hydroxymethylbilane
・ Hydroxymethylfurfural
・ Hydroxymethylglutaryl-CoA hydrolase
・ Hydroxymethylglutaryl-CoA reductase
Hydroxymethylglutaryl-CoA reductase (NADPH)
・ Hydroxymethylglutaryl-CoA synthase
・ Hydroxymethylpentylcyclohexenecarboxaldehyde
・ Hydroxymethylpyrimidine kinase
・ Hydroxymetronidazole
・ Hydroxynaphthol blue
・ Hydroxynaphthoquinone
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・ Hydroxyphenylacetonitrile 2-monooxygenase


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Hydroxymethylglutaryl-CoA reductase (NADPH) : ウィキペディア英語版
Hydroxymethylglutaryl-CoA reductase (NADPH)

In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) () is an enzyme that catalyzes the chemical reaction
:(R)-mevalonate + CoA + 2 NADP+ \rightleftharpoons (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.
== Nomenclature ==

The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:
* hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide
* adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase
* β-hydroxy-β-methylglutaryl coenzyme A reductase
* hydroxymethylglutaryl CoA reductase (NADPH)
* S-3-hydroxy-3-methylglutaryl-CoA reductase
* NADPH-hydroxymethylglutaryl-CoA reductase
* HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
* 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
* hydroxymethylglutaryl-CoA reductase (NADPH2).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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